Saina Doxycycline Hyclate gaosi oloa ma fa'atau |CPF

Doxycycline Hyclate

Fa'amatalaga Puupuu:

Igoa API	Fa'ailoga	Fa'amatalaga	US DMF	EU DMF	CEP
Doxycycline Hyclate	Antibiotic	USP/EP	13771	√

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Fa'amatalaga Oloa

Faailoga o oloa

FAAMATALAGA O MEA FAI

Talaaga

O le Doxycycline hyclate o se vailaau fa'ama'i [1].

O le Doxycycline hyclate o se mea e maua mai i le tetracycline ma o loʻo i ai le gaioiga o le anti-inflammatory ma le antimicrobial.O le Doxycycline e taofia le toe faia o le dengue virus i totonu o le vitro i se faiga e faalagolago i le vevela.Ole tau ole IC50 ole 52.3μM ile 37°C ma le 26.7μM ile 40°C.E taofia le siama dengue e ala i le taofia o le NS2B-NS3 serine protease o le siama.60μM doxycycline fa'aitiitia le CPE o sela fa'ama'i DNEV2 [1].

O le Doxycycline o loʻo maua o se faʻalavelave ole MMP.O togafitiga o le Doxycycline e fa'aitiitia ai le maualuga o le MMP-8 ma le -9 ma fa'alavelaveina le fa'aalia o le tino MMP-2 ma le MMP-9.E le gata i lea, o togafitiga ma le doxycycline e matua faʻaitiitia ai le aʻafiaga o le intracranial aneurysms.O le Doxycycline ua lipotia mai foi e avea o se sui e tetee i le inflammatory e faavae i luga o lona taofiofia o matrix metalloproteinases.E le gata i lea, o le doxycycline o loʻo i ai le malosi o le antimalarial ma le IC50 taua o le 320nM i le 96h in vitro [2, 3].

Fa'asinomaga:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Faʻalavelave faʻalavelave o le doxycycline e faasaga i le dengue virus replication in vitro.Arch Virol.2014 Ape;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Matafaioi o matrix metalloproteinases (MMPs) ma MMP inhibitors i luga o le intracranial aneurysms: o se iloiloga tusiga.Med J Islama Repub Iran.2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro ma in vivo antimalarial aoga o tetracyclines sili ona lelei.Antimicrob Agents Chemother.2013 Iul;57(7):3131-6.

Fa'amatalaga

O le Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), o se vailaʻau faʻamaʻi, o se mea faʻamalosi tautala ma lautele-alaleo metalloproteinase (MMP) inhibitor [1].

Su'ega Fa'afoma'i

Numera NCT	Fesoasoani	Tulaga	Aso Amata	Vaega
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NCT00243893	Iunivesite o Kalefonia, San Francisco\|National Institute of Neurological Disorders and Stroke (NINDS)	Aneurysms\|Ma'i Fa'aletonu le Arteriovenous	Iulai 2004	Vaega 1
NCT00126399	CollaGenex Pharmaceuticals	Rosacea	Iuni 2004	Vaega 3
NCT01318356	Radboud University\|ZonMw: The Netherlands Organization for Health Research and Development	Q Five\|Fatigue Syndrome, Chronic\|Coxiella Infection	Aperila 2011	Vaega 4
NCT00177333	Iunivesite o Pittsburgh	Fa'apa'u, Fa'aoso\|Su'i	Setema 2005	Vaega 4
NCT00007735	US Department of Veterans Affairs\|Pfizer\|United States Department of Defense\|VA Office of Research and Development	Persian Gulf Syndrome\|Mycoplasma Infections	Ianuari 1999	Vaega 3
NCT00351273	Iunivesite o Florida i Saute\|Inisetiute a le Atunu'u o Ga'oto'o ma Musculoskeletal ma Fa'ama'i Pa'u (NIAMS)	Ga'au, Reactive\|Reiter Disease	Me 2006	Vaega 3
NCT00469261	Falemai Careggi	Myocardial Infarction\|Fa'alelei le Ventricular agavale	Me 2007	Vaega 2
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NCT01475708	Falemai Falemai Iunivesite Ljubljana	Lyme Borreliosis	Me 2011
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NCT00066027	Iunivesite o Nebraska\|National Institute of Dental and Craniofacial Research (NIDCR)	Periodontitis	Iuni 2002	Vaega 3
NCT00376493	Falemai o Clinicas de Porto Alegre	Fa'apa'u pepe Septic	Me 2006	Vaega 4
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NCT00000938	National Institute of Allergy and Infectious Diseases (NIAID)	Fa'ama'i Lyme		Vaega 3
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NCT02735837	Amirhossein Farahmand\|Islamic Azad Iunivesite, Tehran	Ma'isuka Mellitus ma le Fa'ama'i Fa'ata'oto	Ianuari 2015	Vaega 2\|Vaega 3
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NCT03585140	Centro Dermatológico Dr. Ladislao de la Pascua	Acne Vulgaris\|Suiga Mea'ai	Ianuari 1, 2016	E le agavaa ai
NCT02147262	Nofoaga Autu Faafomai a le Iunivesite Ljubljana\|Iunivesite o Ljubljana Aoga Faafomai, Slovenia\|Iunivesete Faafomai o Vienna\|Iunivesite Harvard	Acrodermatitis Atrophic tumau	Iulai 2013	E le agavaa ai
NCT02220751	Iunivesite o Sao Paulo\|Fundação de Amparo i Pesquisa do Estado de São Paulo	Periodontitis\|ituaiga 2 Ma'isuka Mellitus	Mati 2009	Vaega 3
NCT01825408	Iunivesite o Karolaina i Matu, Chapel Hill	Sinusitis	Fepuari 2013	Vaega 4
NCT02884713	King Faisal Specialist Hospital & Research Center	GASTRITIS	Iuni 2013	E le agavaa ai
NCT02726646	Iunivesite o Campinas, Pasila\|Pontificia Universidade Catolica de Sao Paulo	Periodontitis tumau	Iuni 2015	Vaega 2
NCT00883818	Samsung Medical Center	Ovatoga Fua'au	Ianuari 2007	Vaega 4
NCT00829790	Teva Pharmaceuticals USA	Soifua maloloina	Oketopa 2006	Vaega 1
NCT01949233	Iunivesite o Oxford\|Oxford University Hospitals NHS Trust	Fa'ama'i o Marfan	Oketopa 2013	Vaega 2
NCT01518192	Falema'i Falema'i Iunivesite Ljubljana\|Slovenian Research Agency	Erythema Migrans\|Fa'ailoga Fa'ama'i Post-Lyme	Iuni 2006	Vaega 4
NCT02845024	Iunivesite Islam Azad, Tehran	Ma'isuka Mellitus ma le Fa'ama'i Fa'ata'oto	Setema 2014	E le agavaa ai
NCT01879930	Falemai Iunivesite Inselspital, Berne	Fa'ama'i Fa'ama'i Fa'ama'i Fa'ama'i Fa'ama'i \|	Novema 2012	Vaega 4
NCT00041977	CollaGenex Pharmaceuticals	Acne Rosacea	Iuni 2002	Vaega 3
NCT02341209	Rochester General Hospital	Lymphoma T-selau pa'u \| Mycosis Fungoides\|Sezary Syndrome	Fepuari 6, 2018	Vaega 2
NCT00002872	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|North Central Cancer Treatment Group	Kanesa Metastatic	Novema 1996	Vaega 3
NCT03162497	Iunivesite Faafomai o Vienna	Fa'ama'i Mata mago\|Meibomian Gland Disfunction	Ianuari 8, 2018	Vaega 4
NCT01418742	Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH\|ClinAssess GmbH	Carcinoma Colorectal	Aokuso 2011	Vaega 2
NCT00980148	National Institute of Allergy and Infectious Diseases (NIAID)	Fa'ama'i Chlamydial	Tesema 2009	Vaega 3
NCT03342456	Le Tolu Falemai Xiangya o Central South Iunivesite\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm.Ind. Co., Ltd.	Duodenal ulcer ona o le Helicobacter Pylori	Tesema 13, 2017	Vaega 4
NCT04310930	O le Iunivesite o Kuiniselani\|Matagaluega o le Soifua Maloloina a le Malo Ausetalia\|Faavae Falemai o Tamaiti\|Cystic Fibrosis Foundation\|University Newcastle\|University Griffith\|Erasmus Medical Center\|Monash University\|University of Copenhagen\|Hôpital Cochin\|South Australian Health and Medical Research Institute\|Iunivesite o Melepone\|Iunivesite James Cook, Kuiniselani, Ausetalia\|Murdoch Childrens Research Institute	Fa'ama'i Fa'ama'i ona o le Mycobacteria (Su'esu'ega)	Mati 2020	Vaega 2\|Vaega 3
NCT03709459	Kirby Institute\|South Australian Health and Medical Research Institute\|Monash University	Puipuiga ole STI	Tesema 17, 2019
NCT04067011	Emergent BioSolutions\|Biomedical Advanced Research and Development Authority	Anthrax	Aokuso 12, 2019	Vaega 2
NCT02844634	British Columbia Centre mo Fa'ama'i Pulea	HIV\|Sifili	Me 15, 2018	Vaega 4
NCT00647959	Mylan Pharmaceuticals	Soifua maloloina	Mati 2006	Vaega 1
NCT00170222	Falema'i Falema'i Alkmaar	Fa'ama'i Fa'alavelave Fa'alavelave	Iulai 2002	Vaega 4
NCT03075891	Galderma	Rosacea	Iulai 5, 2017	Vaega 4
NCT00031499	National Institute of Allergy and Infectious Diseases (NIAID)	Sifilis	Iuni 2000	Vaega 3
NCT01205464	Iunivesite o Linkoeping	Lelavai\|Tiga Radicular\|Fa'aletonu o le mafaufau\|Paresthesia\|Paresis	Fepuari 2005	E le agavaa ai
NCT01301586	Nexgen Dermatologics, Inc.	ACNE VULGARIS	Novema 2010	Vaega 1\|Vaega 2
NCT02305940	Kolisi Imperial Lonetona	Fa'ama'i Fa'alavelave Fa'alavelave (COPD)	Iulai 2014	Vaega 3
NCT00351182	Dong-Min Kim\|Chosun University Hospital	Fufulu Typhus	Setema 2005	Vaega 3
NCT03334682	Falemai a le Iunivesite o Nantes	Acne Vulgaris	Ianuari 31, 2018	Vaega 3
NCT01788215	Iunivesite o Rochester	Polycystic Ovarian Syndrome (PCOS)\|Ta'amilosaga Fa'aletonu o le Ma'itaga\|Ova atu o le Androgen	Novema 2010	Vaega 3
NCT03076281	Sidney Kimmel Cancer Center i le Iunivesite o Thomas Jefferson\|University Thomas Jefferson	Larynx\|LIP\|Oga gutu\|Pharynx	Aperila 3, 2017	Vaega 2
NCT00439166	Hamilton Health Sciences Corporation\|The Physicians' Services Incorporated Foundation\|McMaster University	Fa'ama'i o le Alzheimer	Fepuari 2007	Vaega 3
NCT02463942	University Medical Center Ljubljana\|Iunivesite o Ljubljana School of Medicine, Slovenia	Encephalitis e mafua mai i le su'ega	Setema 2014	E le agavaa ai
NCT00803842	Iunivesite i Matu sisifo	Le Kanesa Laiti Selula Mama	Oketopa 2008	E le agavaa ai
NCT02086591	Iunivesite o Rochester	Tagata Matutua Fa'asalalauina La'au B-Cell Lymphoma\|Mantle Cell Lymphoma Toe'u\|Lymphoma, Follicular\|Marginal Zone B-Cell Lymphoma\|Lifoma Mata'utia - Lymphoplasmacytic\|Waldenstrom Macroglobulinemia\|Laiti Lymphocytic Lymphoma\|Chronic Lymphocytic Lymphoma (CLL) Leukemia	Mati 2014	Vaega 2
NCT03980223	Iunivesite o Kalefonia, San Francisco\|Iunivesete o Uosigitone\|National Institute of Allergy and Infectious Diseases (NIAID)\|Mayne Pharma International Pty Ltd\|San Francisco Department of Public Health	Gonorrhea\|Chlamydia\|Syphilis	Novema 26, 2019	Vaega 4
NCT00355459	Iunivesite o Texas Southwestern Medical Center	Ma'i Mata mago	Aokuso 2005	E le agavaa ai
NCT01254799	Omar Mamdouh Shaaban\|Iunivesite Assiut	Fa'atoto o le Uterine	Ianuari 2008	Vaega 3
NCT01547325	NanoSHIFT LLC\|Matagaluega o Puipuiga a le Iunaite Setete	Manu'a Ta'oto'otoga	Me 2012	E le agavaa ai
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi	Setema 1999	Vaega 1
NCT00635609	Warner Chilcott	Acne Vulgaris	Mati 2008	Vaega 4
NCT03765931	Institut de Recherche pour le Atiina'e	Fiva	Iulai 2016	Vaega 4
NCT01160640	Harold Wiesenfeld\|National Institute of Allergy and Infectious Diseases (NIAID)\|Iunivesite o Pittsburgh	Fa'ama'i Fua o le Pelvic	Novema 2010	Vaega 2
NCT01756833	Iunivesite o Maryland, Baltimore\|National Institute on Aging (NIA)	Aneurysm	Me 2013	Vaega 2
NCT00688064	Galderma	Mata'utia Acne Vulgaris	Aokuso 2008	Vaega 3
NCT01320033	Galderma	Acne Vulgaris	Mati 29, 2011	Vaega 2
NCT03397004	St. Michael's Hospital, Toronto\|Barrow Neurological Institute\|Duke University\|Feinstein Institute for Medical Research\|University of Pittsburgh\|Sunnybrook Health Sciences Center	Telangiectasia Fa'atosina (HHT)	Setema 12, 2018	Vaega 2
NCT01635530	Falemai i le Iunivesite o Turku	Lyme Neuroborreliosis	Aokuso 2012	Vaega 4
NCT03727620	Iunivesite o Mohammed V Souissi	Periodontitis fa'aleaga	Ianuari 6, 2014	Vaega 1\|Vaega 2
NCT02688738	Rothman Institute Orthopedics	Propionibacterium	Mati 2015	E le agavaa ai
NCT00358462	Iunivesite o Uosigitone\|National Institute of Allergy and Infectious Diseases (NIAID)	Uretritis	Ianuari 2007	Vaega 3
NCT02864550	British Columbia Centre mo Fa'ama'i Pulea	Syphilis\|Fa'ama'i Fa'afeusuaiga	Aokuso 15, 2019	Vaega 4
NCT01595594	Iunivesite o Sao Paulo\|Fundação de Amparo i Pesquisa do Estado de São Paulo	Fa'ama'i Fa'avaitaimi\|Ma'isuka Ituaiga 2	Mati 2010	Vaega 3
NCT00964834	PharmAthene, Inc.\|National Institute of Health (NIH)\|Medarex\|Quintiles, Inc.\|Matagaluega o le Soifua Maloloina ma Auaunaga Tagata	Anthrax	Iulai 2009	Vaega 1
NCT01809444	Sun Yat-sen Iunivesite	Ophtalmopathies e feso'ota'i ile thyroid	Novema 2012	Vaega 2\|Vaega 3
NCT01590082	MD Anderson Cancer Center\|A'oga Fa'alesoifua maloloina a le Atunu'u (NIH)\|Inisetiute Kanesa a le Atunu'u (NCI)	Melanoma	Novema 2012	Vaega 1\|Vaega 2
NCT00207584	Nofoaga Autu mo Fa'ama'i ma Puipuiga	Mycoplasma Pneumoniae	Ianuari 1994	E le agavaa ai
NCT00775177	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Soifua maloloina	Iuni 2005	E le agavaa ai
NCT03462329	Falemai Falemai Iunivesite Ljubljana	Erythema Migrans	Iuni 1, 2018	E le agavaa ai
NCT00000403	Iunivesite o Indiana\|Inisetiute a le Atunu'u o Fa'ama'i Fa'ama'i ma Musculoskeletal ma Fa'ama'i Pa'u (NIAMS)\|Inisetiute a le Atunu'u mo le Matutua (NIA)	Osteoarthritis	Setema 1996	Vaega 3
NCT03508232	Iunivesite o Alberta\|Royal Alexandra Hospital	ST Segment Elevation Myocardial Infarction\|Fa'ato'i le fatu	Ianuari 6, 2020	Vaega 2
NCT02553473	Falemai Sorlandet HF	Neuroborreliosis, Borrelia Burgdorferi	Oketopa 2015	Vaega 3
NCT02207556	Kolisi Faafomai a Wisconsin	Primary Systemic Amyloidosis	Oketopa 1, 2014	Vaega 2
NCT01783106	Falemai a le Iunivesite a le Royal Liverpool\|National Association for Colitis and Crohn's Disease\|National Institute for Health Research, United Kingdom	Fa'ama'i a Crohn	Fepuari 1, 2014	Vaega 2
NCT00353743	Falemai o Clinicas de Porto Alegre	Fa'apa'u pepe, Septic	Me 2006	E le agavaa ai
NCT01727973	Sun Yat-sen Iunivesite	Graves Ophthalmopathy\|Ma'i Tu'ugamau\|Ma'i Mata\|Ma'i Gaooti\|Ma'i Fa'ama'i Endocrine\|Ma'i Mata, Tu'ufua\|Hyperthyroidism\|Ma'i Autoimmune\|Ma'i Fa'ama'i	Oketopa 2012	Vaega 1\|Vaega 2
NCT00857038	Medical Center Alkmaar\|Leiden University Medical Center\|Iunivesite o Amsterdam	Fa'ama'i Fa'ama'i Fa'agata\|Fula\|Emphysema Pula	Aperila 2009	Vaega 4
NCT02774993	Falemai a le Iunivesite Aoao, Sigapoa\|Tagata Tock Seng Falemai\|Iunivesite a le Atunuu, Sigapoa\|A* Fetu	Tuberculosis	Setema 2015	Vaega 2
NCT03474458	IRCCS Policlinico S. Matteo	Cardiac AL Amyloidosis	Fepuari 11, 2019	Vaega 2\|Vaega 3
NCT02874430	Sidney Kimmel Cancer Center i le Iunivesite o Thomas Jefferson\|University Thomas Jefferson	Ma'i o le susu\|Adenocarcinoma o le susu o le fa'a'au'au \|	Iuni 8, 2016	Vaega 2
NCT00016835	Iunivesite o Michigan\|National Institute of Dental and Craniofacial Research (NIDCR)	Fa'ama'i Fa'ata'oto\|Ma'isuka Mellitus, Ituaiga 2	Oketopa 17, 2001	Vaega 2
NCT00064766	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Fa'ama'i Fa'ama'i Fa'ama'i	Fepuari 2003	Vaega 4
NCT00803452	Iunivesite o Louisville	Blepharitis	Iulai 2008	Vaega 4
NCT01434173	Bayer\|RTI Health Solutions	Manu'a ile ate ona o fualaau	Iulai 2001
NCT00126204	Barnes-Jewish Hospital	Aortic Aneurysm	Mati 2004	E le agavaa ai
NCT01917721	Hawaii Pacific Health	Fa'ama'i Kawasaki\|Coronary Aneurysm	Oketopa 2013	Vaega 2
NCT02775695	Kolisi Faafomai a Wisconsin	Kanesa Pancreatic Resectable	Aperila 3, 2017	Vaega 2
NCT03824340	Falema'i Aljazeera	Le fanautama	Ianuari 30, 2019	E le agavaa ai
NCT01847976	Ottawa Hospital Research Institute\|Canadian Breast Cancer Foundation	tiga	Aokuso 2013	Vaega 2
NCT02850913	Iunivesite o Makerere\|Iunivesite o Oxford	Faoa faamalosi	Setema 5, 2016	Vaega 2
NCT00764361	NanoSHIFT LLC	Ma'isuka Fuagavae	Ianuari 2009	Vaega 2
NCT02036528	Royer Biomedical, Inc.	Ma'isuka vae ma'i	Ianuari 2014	Vaega 1\|Vaega 2
NCT01661985	Ostergotland County Council, Suetena\|Statens Serum Institut	Urethritis\|Cervicitis\|Fa'ama'i Mycoplasma Genital\|Chlamydia Trachomatis	Fepuari 2010	Vaega 4
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi	Ianuari 2000	Vaega 1
NCT00648180	Mylan Pharmaceuticals	Soifua maloloina	Iulai 2005	Vaega 1
NCT01426269	Galderma Laboratories, LP	Rosacea	Setema 2011	Vaega 4
NCT02753426	Iunivesite o Kalefonia, San Francisco	Fa'ama'i fatuga'o tumau\|Ma'i fatu fatu	Aperila 2016	Vaega 1
NCT02583282	Postgraduate Institute of Medical Education and Research	Fa'aleaga Pleural Effusion	Aokuso 1, 2015	E le agavaa ai
NCT02927496	Le Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema\|Lymphatic Filariasis\|Filariasis	Iuni 19, 2018	Vaega 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi	Iulai 2004	Vaega 1
NCT03956212	University Medical Center Ljubljana\|Iunivesite o Ljubljana School of Medicine, Slovenia	Erythema Migrans	Iuni 1, 2017	E le agavaa ai
NCT00855595	Bayer	Papulopustular Rosacea	Fepuari 2009	Vaega 4
NCT03457636	Derm Research, PLLC	Ga'u	Mati 19, 2018	Vaega 4
NCT02894268	Sir Run Run Shaw Hospital	Fa'ama'i Helicobacter Pylori	Fepuari 2016	Vaega 4
NCT03465774	MD Anderson Cancer Center\|National Cancer Institute (NCI)	Fa'aleaga Pleural Effusion	Mati 8, 2018	Laasaga Muamua 1