Dabigatran Etexilate Mesylate

Fa'amatalaga Puupuu:

Igoa API Fa'ailoga Fa'amatalaga US DMF EU DMF CEP
Dabigatran Etexilate Mesylate Anticoagulant I totonu o le Fale      


Fa'amatalaga Oloa

Faailoga o oloa

FAAMATALAGA O MEA FAI

Fa'amatalaga

O le Dabigatran etexilate mesylate (BIBR 1048MS) o se vailaʻau faʻamalosi tautala a Dabigatran.Dabigatran etexilate mesylate ei ai aʻafiaga anticoagulant ma faʻaaogaina mo le puipuia o le venousthromboembolism ma le stroke ona o le fibrillation atrial.

Talaaga

Faʻamatalaga: IC50 Taua: 4.5nM (Ki);10nM(Thrombin-induced platelet aggregation) [1] O le Dabigatran o se mea e mafai ona toe fa'afo'i ma filifili, fa'atosina sa'o o le thrombin (DTI) o lo'o fa'aauau le atina'eina o falema'i e avea o ana vaila'au fa'amalosi tautala, dabigatran etexilate.in vitro: Dabigatran filifili ma toe faʻafefe le thrombin tagata (Ki: 4.5 nM) faʻapea foʻi ma le thrombin-induced platelet aggregation (IC(50): 10 nM), aʻo faʻaalia le leai o se aʻafiaga i luga o isi platelet-stimulating agents.Thrombin generation in platelet -mativa plasma (PPP), fuaina e pei o le endogenous thrombin gafatia (ETP) na taofia le faʻalagolago-faʻalagolago (IC(50): 0.56 microM).Na faʻaalia e Dabigatran aʻafiaga o le anticoagulant faʻalagolago i le faʻaogaina i ituaiga eseese i vitro, faʻaluaina le taimi o le thromboplastin faʻagaoioia (aPTT), taimi o le prothrombin (PT) ma le taimi o le ecarin clotting (ECT) i le PPP tagata i le faʻaogaina o le 0.23, 0.83 ma le 0.18 microM, i le faasologa. 1].i vivo: Dabigatran fa'aumi le fua aPTT-fa'alagolago pe a uma le fa'aogaina o le toto i isumu (0.3, 1 ma le 3 mg/kg) ma manuki rhesus (0.15, 0.3 ma le 0.6 mg/kg).O aʻafiaga faʻamalosi ma faʻalagolago i le taimi na matauina i le dabigatran etexilate na tuʻuina tautala i isumu (10, 20 ma 50 mg / kg) poʻo manuki rhesus (1, 2.5 poʻo le 5 mg / kg), ma le maualuga o aʻafiaga na matauina i le va o le 30 ma le 120. min pe a uma le faʻatonuga, faʻasologa [1].O ma'i na togafitia i le dabigatran etexilate na maua ni nai ta'i fa'ama'i (3.74 dabigatran etexilate vs 3.97 warfarin) ma fa'aitiitia le tu'ufa'atasia o le toto toto ma le fa'ama'i (0.43 dabigatran etexilate vs 0.99 warfarin) i le 100 ma'i-tausaga].Faʻataʻitaʻiga faʻapitoa: O se Iloiloga o Pharmacokinetics ma Pharmacodynamics o le Oral Dabigatran Etexilate i Maʻi Hemodialysis.Vaega1

Teuina

Pa'u

-20°C

3 tausaga
 

4°C

2 tausaga
I solvent

-80°C

6 masina
 

-20°C

1 masina

Su'ega Fa'afoma'i

Numera NCT Fesoasoani Tulaga Aso Amata

Vaega

NCT02170792 Boehringer Ingelheim Soifua maloloina Fepuari 2001

Vaega 1

NCT02170974 Boehringer Ingelheim Soifua maloloina Iulai 2004

Vaega 1

NCT02170831 Boehringer Ingelheim Soifua maloloina Me 1999

Vaega 1

NCT02170805 Boehringer Ingelheim Soifua maloloina Aperila 2001

Vaega 1

NCT02170610 Boehringer Ingelheim Soifua maloloina Mati 2002

Vaega 1

NCT02170909 Boehringer Ingelheim Soifua maloloina Tesema 2004

Vaega 1

NCT02171000 Boehringer Ingelheim Soifua maloloina Aperila 2005

Vaega 1

NCT02170844 Boehringer Ingelheim Soifua maloloina Iuni 2004

Vaega 1

NCT02170584 Boehringer Ingelheim Soifua maloloina Ianuari 2001

Vaega 1

NCT02170935 Boehringer Ingelheim Venous Thromboembolism Aperila 2002

Vaega 2

NCT02170636 Boehringer Ingelheim Soifua maloloina Ianuari 2002

Vaega 1

NCT02170766 Boehringer Ingelheim Soifua maloloina Oketopa 2000

Vaega 1

NCT02171442 Boehringer Ingelheim Soifua maloloina Aperila 2002

Vaega 1

NCT02170896 Boehringer Ingelheim Soifua maloloina Oketopa 2001

Vaega 1

NCT02173730 Boehringer Ingelheim Soifua maloloina Novema 2002

Vaega 1

NCT02170623 Boehringer Ingelheim Soifua maloloina Fepuari 2002

Vaega 1

NCT02170116 Boehringer Ingelheim Soifua maloloina Novema 1998

Vaega 1

NCT02170597 Boehringer Ingelheim Soifua maloloina Aokuso 2003

Vaega 1

NCT01225822 Boehringer Ingelheim Venous Thromboembolism Novema 2002

Vaega 2

NCT02170701 Boehringer Ingelheim Venous Thromboembolism Oketopa 2000

Vaega 2

NCT02170740 Boehringer Ingelheim Soifua maloloina Novema 1999

Vaega 1

NCT02170922 Boehringer Ingelheim Soifua maloloina Iulai 1999

Vaega 1

Fa'asologa o vaila'au

Dabigatran Etexilate Mesylate

PULEGA UIGA

Quality management1

Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6o lo'o i lalo le faamaoniga.

Quality management2

A'oa'oga fa'ava-o-malo pulega lelei faiga ua faataatia faavae mautu mo le faatauina atu.

Quality management3

O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.

Quality management4

E lagolagoina e le vaega o Mataupu Tau Fa'apolofesa tulaga mana'omia ile taimi ole talosaga ma le resitalaina.

PULEGA O GALUEGA

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Italia CAM Board Packaging Line

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Siamani Fette Compacting Machine

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Iapani Viswill Tablet Su'esu'e

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