Doxycycline Hyclate
Talaaga
O le Doxycycline hyclate o se vailaau fa'ama'i [1].
O le Doxycycline hyclate o se mea e maua mai i le tetracycline ma o loʻo i ai gaioiga o le anti-inflammatory ma antimicrobial. O le Doxycycline e taofia ai le toe faia o le dengue virus i totonu o le vitro i se faiga e faalagolago i le vevela. Ole tau ole IC50 ole 52.3μM ile 37°C ma le 26.7μM ile 40°C. E taofia le siama dengue e ala i le taofia o le NS2B-NS3 serine protease o le siama. 60μM doxycycline e faʻaitiitia ai le CPE o sela faʻamaʻi DNEV2 [1].
O le Doxycycline o loʻo maua o se faʻalavelave ole MMP. O togafitiga o le Doxycycline e fa'aitiitia ai le maualuga o le MMP-8 ma le -9 ma fa'alavelaveina le fa'aalia o le tino MMP-2 ma le MMP-9. E le gata i lea, o togafitiga ma le doxycycline e matua faʻaitiitia ai le aʻafiaga o le intracranial aneurysms. O le Doxycycline ua lipotia mai foi e avea o se sui e tetee i le inflammatory e faavae i luga o lona taofiofia o matrix metalloproteinases. E le gata i lea, o le doxycycline e iai le malosi o le antimalarial ma le IC50 tau o le 320nM i le 96h in vitro [2, 3].
Fa'asinomaga:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Aafiaga faʻalavelave o le doxycycline faasaga i le faʻamaʻiina o le dengue virus in vitro. Arch Virol. 2014 Ape;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Matafaioi o matrix metalloproteinases (MMPs) ma MMP inhibitors i luga o le intracranial aneurysms: o se tusiga iloiloga. Med J Islama Repub Iran. 2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro ma in vivo antimalarial aoga o tetracyclines sili ona lelei. Antimicrob Agents Chemother. 2013 Iul;57(7):3131-6.
Fa'amatalaga
O le Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), o se vailaʻau faʻamaʻi, o se mea faʻamalosi tautala ma lautele-alaleo metalloproteinase (MMP) inhibitor [1].
Tofotofoga Fa'afoma'i
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NCT02726646 | Iunivesite o Campinas, Pasila|Pontificia Universidade Catolica de Sao Paulo | Periodontitis tumau | Iuni 2015 | Vaega 2 |
NCT00883818 | Samsung Medical Center | Ovatoga Fua'au | Ianuari 2007 | Vaega 4 |
NCT00829790 | Teva Pharmaceuticals USA | Soifua maloloina | Oketopa 2006 | Vaega 1 |
NCT01949233 | Iunivesite o Oxford|Oxford University Hospitals NHS Trust | Fa'ama'i o Marfan | Oketopa 2013 | Vaega 2 |
NCT01518192 | Nofoaga Autu Faafomai a le Iunivesite Ljubljana|Slovenian Research Agency | Erythema Migrans|Fa'ailoga Fa'ama'i Post-Lyme | Iuni 2006 | Vaega 4 |
NCT02845024 | Islamic Azad Iunivesite, Tehran | Ma'isuka Mellitus ma le Fa'ama'i Fa'ata'oto | Setema 2014 | E le agavaa ai |
NCT01879930 | Falemai Iunivesite Inselspital, Berne | Fa'ama'i Fa'ama'i Fa'ama'i Fa'ama'i | | Novema 2012 | Vaega 4 |
NCT00041977 | CollaGenex Pharmaceuticals | Acne Rosacea | Iuni 2002 | Vaega 3 |
NCT02341209 | Falemai Tele a Rochester | Lymphoma T-cell Pa'u |Mycosis Fungoides|Sezary Syndrome | Fepuari 6, 2018 | Vaega 2 |
NCT00002872 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group | Kanesa Metastatic | Novema 1996 | Vaega 3 |
NCT03162497 | Iunivesite Faafomai o Vienna | Ma'i Mata Mamago|Meibomian Gland Fa'aletonu | Ianuari 8, 2018 | Vaega 4 |
NCT01418742 | Gesellschaft fur Medizinische Innovation ? Hamatologie und Onkologie mbH|ClinAssess GmbH | Fa'aa'ai o le colorectal carcinoma | Aokuso 2011 | Vaega 2 |
NCT00980148 | National Institute of Allergy and Infectious Diseases (NIAID) | Fa'ama'i Chlamydial | Tesema 2009 | Vaega 3 |
NCT03342456 | Le Tolu Falemai Xiangya o Central South Iunivesite|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm. Ind. Co., Ltd. | Duodenal ulcer ona o le Helicobacter Pylori | Tesema 13, 2017 | Vaega 4 |
NCT04310930 | Le Iunivesite o Kuiniselani|Matagaluega o le Soifua Maloloina a le Malo Ausetalia|Faavae Falemai o Tamaiti|Cystic Fibrosis Foundation|University Newcastle|University Griffith|Erasmus Medical Center|Monash University|University of Copenhagen|Hôpital Cochin|South Australian Health and Medical Research Institute|Iunivesite o Melepone|Iunivesite James Cook, Kuiniselani, Ausetalia|Murdoch Childrens Research Institute | Fa'ama'i Fa'ama'i ona o le Mycobacteria (Su'esu'ega) | Mati 2020 | Vaega 2|Vaega 3 |
NCT03709459 | Kirby Institute|South Australian Health and Medical Research Institute|Monash University | Puipuiga ole STI | Tesema 17, 2019 |
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NCT04067011 | Emergent BioSolutions|Biomedical Advanced Research and Development Authority | Anthrax | Aokuso 12, 2019 | Vaega 2 |
NCT02844634 | British Columbia Centre mo Fa'ama'i Pulea | HIV|Sifilis | Me 15, 2018 | Vaega 4 |
NCT00647959 | Mylan Pharmaceuticals | Soifua maloloina | Mati 2006 | Vaega 1 |
NCT00170222 | Falemai Falemai Alkmaar | Fa'ama'i Fa'alavelave Fa'alavelave | Iulai 2002 | Vaega 4 |
NCT03075891 | Galderma | Rosacea | Iulai 5, 2017 | Vaega 4 |
NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | Sifilis | Iuni 2000 | Vaega 3 |
NCT01205464 | Iunivesite o Linkoeping | Lelavai|Tiga Radicular|Fa'aletonu o le mafaufau|Paresthesia|Paresis | Fepuari 2005 | E le agavaa ai |
NCT01301586 | Nexgen Dermatologics, Inc. | ACNE VULGARIS | Novema 2010 | Vaega 1|Vaega 2 |
NCT02305940 | Kolisi Imperial Lonetona | Fa'ama'i Fa'alavelave Fa'afuase'i (COPD) | Iulai 2014 | Vaega 3 |
NCT00351182 | Dong-Min Kim|Chosun University Hospital | Fufulu Typhus | Setema 2005 | Vaega 3 |
NCT03334682 | Falemai a le Iunivesite o Nantes | Acne Vulgaris | Ianuari 31, 2018 | Vaega 3 |
NCT01788215 | Iunivesite o Rochester | Polycystic Ovarian Syndrome (PCOS)|Ta'amilosaga Fa'aletonu o le Ma'itaga|Ova o le Androgen | Novema 2010 | Vaega 3 |
NCT03076281 | Sidney Kimmel Cancer Center i le Iunivesite o Thomas Jefferson|University Thomas Jefferson | Larynx|LIP|Oga gutu|Pharynx | Aperila 3, 2017 | Vaega 2 |
NCT00439166 | Hamilton Health Sciences Corporation|The Physicians' Services Incorporated Foundation|McMaster University | Fa'ama'i o le Alzheimer | Fepuari 2007 | Vaega 3 |
NCT02463942 | University Medical Center Ljubljana|Iunivesite o Ljubljana School of Medicine, Slovenia | Encephalitis e mafua mai i le togi | Setema 2014 | E le agavaa ai |
NCT00803842 | Iunivesite i Matu sisifo | Kanesa o le Mama e le o sela laiti | Oketopa 2008 | E le agavaa ai |
NCT02086591 | Iunivesite o Rochester | Tagata Matutua Ta'ape'a La'au B-Cell Lymphoma|Mantle Cell Lymphoma Recurre|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Limphoma Mata'utia - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|La'iti Lymphocytic Lymphoma|Chronic Lymphocytic Lymphoma (CLL) LymphomaTilimia (CLL) | Mati 2014 | Vaega 2 |
NCT03980223 | Iunivesite o Kalefonia, San Francisco|Iunivesete o Uosigitone|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|San Francisco Department of Public Health | Gonorrhea|Chlamydia|Syphilis | Novema 26, 2019 | Vaega 4 |
NCT00355459 | Iunivesite o Texas Southwestern Medical Center | Ma'i Mata mago | Aokuso 2005 | E le agavaa ai |
NCT01254799 | Omar Mamdouh Shaaban|Iunivesite Assiut | Fa'ato'a toto | Ianuari 2008 | Vaega 3 |
NCT01547325 | NanoSHIFT LLC|Matagaluega o Puipuiga a le Iunaite Setete | Manu'a Ta'oto'otoga | Me 2012 | E le agavaa ai |
NCT00653380 | Par Pharmaceutical, Inc.|Anapharm | E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi | Setema 1999 | Vaega 1 |
NCT00635609 | Warner Chilcott | Acne Vulgaris | Mati 2008 | Vaega 4 |
NCT03765931 | Institut de Recherche pour le Atiina'e | Fiva | Iulai 2016 | Vaega 4 |
NCT01160640 | Harold Wiesenfeld|National Institute of Allergy and Infectious Diseases (NIAID)|Iunivesite o Pittsburgh | Fa'ama'i Fua o le Pepe | Novema 2010 | Vaega 2 |
NCT01756833 | Iunivesite o Maryland, Baltimore|National Institute on Aging (NIA) | Aneurysm | Me 2013 | Vaega 2 |
NCT00688064 | Galderma | Mata'utia Acne Vulgaris | Aokuso 2008 | Vaega 3 |
NCT01320033 | Galderma | Acne Vulgaris | Mati 29, 2011 | Vaega 2 |
NCT03397004 | St. Michael's Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|University of Pittsburgh|Sunnybrook Health Sciences Center | Telangiectasia Tu'ufa'atasia (HHT) | Setema 12, 2018 | Vaega 2 |
NCT01635530 | Falemai i le Iunivesite o Turku | Lyme Neuroborreliosis | Aokuso 2012 | Vaega 4 |
NCT03727620 | Iunivesite o Mohammed V Souissi | Periodontitis fa'aleaga | Ianuari 6, 2014 | Vaega 1|Vaega 2 |
NCT02688738 | Rothman Institute Orthopedics | Propionibacterium | Mati 2015 | E le agavaa ai |
NCT00358462 | Iunivesite o Uosigitone|National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Ianuari 2007 | Vaega 3 |
NCT02864550 | British Columbia Centre mo Fa'ama'i Pulea | Syphilis|Fa'ama'i Fa'afeusuaiga | Aokuso 15, 2019 | Vaega 4 |
NCT01595594 | Iunivesite o Sao Paulo|Fundação de Amparo i Pesquisa do Estado de São Paulo | Fa'ama'i Fa'avaitaimi|Ma'isuka Ituaiga 2 | Mati 2010 | Vaega 3 |
NCT00964834 | PharmAthene, Inc.|National Institute of Health (NIH)|Medarex|Quintiles, Inc.|Matagaluega o le Soifua Maloloina ma Auaunaga Tagata | Anthrax | Iulai 2009 | Vaega 1 |
NCT01809444 | Iunivesite o Sun Yat-sen | Ophtalmopathies e feso'ota'i ile thyroid | Novema 2012 | Vaega 2|Vaega 3 |
NCT01590082 | MD Anderson Cancer Center|A'oga Fa'alesoifua maloloina a le Atunu'u (NIH)|Inisetiute Kanesa a le Atunu'u (NCI) | Melanoma | Novema 2012 | Vaega 1|Vaega 2 |
NCT00207584 | Nofoaga Autu mo Fa'ama'i ma Puipuiga | Mycoplasma Pneumoniae | Ianuari 1994 | E le agavaa ai |
NCT00775177 | Ranbaxy Laboratories Limited|Ranbaxy Inc. | Soifua maloloina | Iuni 2005 | E le agavaa ai |
NCT03462329 | Falemai Falemai Iunivesite Ljubljana | Erythema Migrans | Iuni 1, 2018 | E le agavaa ai |
NCT00000403 | Iunivesite o Indiana|Inisetiute a le Atunu'u o Fa'ama'i Fa'ama'i ma Musculoskeletal ma Fa'ama'i Pa'u (NIAMS)|Inisetiute a le Atunu'u i le Matutua (NIA) | Osteoarthritis | Setema 1996 | Vaega 3 |
NCT03508232 | Iunivesite o Alberta|Royal Alexandra Hospital | ST Segment Elevation Myocardial Infarction|Fa'ato'ilalo le fatu | Ianuari 6, 2020 | Vaega 2 |
NCT02553473 | Falemai Sorlandet HF | Neuroborreliosis, Borrelia Burgdorferi | Oketopa 2015 | Vaega 3 |
NCT02207556 | Kolisi Faafomai a Wisconsin | Primary Systemic Amyloidosis | Oketopa 1, 2014 | Vaega 2 |
NCT01783106 | Falemai o le Iunivesite a le Royal Liverpool|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom | Fa'ama'i a Crohn | Fepuari 1, 2014 | Vaega 2 |
NCT00353743 | Falemai o Clinicas de Porto Alegre | Fa'apa'u pepe, Septic | Me 2006 | E le agavaa ai |
NCT01727973 | Iunivesite o Sun Yat-sen | Graves Ophthalmopathy|Ma'i Tu'ugamau|Ma'i Mata|Ma'i Gaoio|Ma'i Fa'ama'i Endocrine|Ma'i Mata, Tu'ufua|Hyperthyroidism|Ma'i Autoimmune|Ma'i Fa'ama'i | Oketopa 2012 | Vaega 1|Vaega 2 |
NCT00857038 | Medical Center Alkmaar|Leiden University Medical Center|Iunivesite o Amsterdam | Fa'ama'i Fa'ama'i Fa'agata|Fula|Emphysema Pula | Aperila 2009 | Vaega 4 |
NCT02774993 | Falemai a le Iunivesite Aoao, Sigapoa | Falemai Tan Tock Seng | Iunivesite Aoao, Sigapoa | A * Fetu | Tuberculosis | Setema 2015 | Vaega 2 |
NCT03474458 | IRCCS Policlinico S. Matteo | Fa'atotonuga AL Amyloidosis | Fepuari 11, 2019 | Vaega 2|Vaega 3 |
NCT02874430 | Sidney Kimmel Cancer Center i le Iunivesite o Thomas Jefferson|University Thomas Jefferson | Kasina o le susu|Adenocarcinoma o le susu o le susu | | Iuni 8, 2016 | Vaega 2 |
NCT00016835 | Iunivesite o Michigan|National Institute of Dental and Craniofacial Research (NIDCR) | Fa'ama'i Fa'aipoipo|Ma'isuka Mellitus, Ituaiga 2 | Oketopa 17, 2001 | Vaega 2 |
NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Fa'ama'i Fa'ama'i Fa'ama'i | Fepuari 2003 | Vaega 4 |
NCT00803452 | Iunivesite o Louisville | Blepharitis | Iulai 2008 | Vaega 4 |
NCT01434173 | Bayer|RTI Health Solutions | Manu'a ile ate ona o fualaau | Iulai 2001 |
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NCT00126204 | Falemai Barnes-Iutaia | Aortic Aneurysm | Mati 2004 | E le agavaa ai |
NCT01917721 | Hawaii Pacific Health | Fa'ama'i Kawasaki|Conory Aneurysm | Oketopa 2013 | Vaega 2 |
NCT02775695 | Kolisi Faafomai a Wisconsin | Kanesa Pancreatic Resectable | Aperila 3, 2017 | Vaega 2 |
NCT03824340 | Falemai Aljazeera | Le fanautama | Ianuari 30, 2019 | E le agavaa ai |
NCT01847976 | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | tiga | Aokuso 2013 | Vaega 2 |
NCT02850913 | Makerere Iunivesite|Iunivesite o Oxford | Faoa faamalosi | Setema 5, 2016 | Vaega 2 |
NCT00764361 | NanoSHIFT LLC | Ma'isuka Fuagavae | Ianuari 2009 | Vaega 2 |
NCT02036528 | Royer Biomedical, Inc. | Ma'isuka Fuavae | Ianuari 2014 | Vaega 1|Vaega 2 |
NCT01661985 | Ostergotland County Council, Suetena|Statens Serum Institut | Urethritis|Cervicitis|Fa'ama'i Mycoplasma Genital|Chlamydia Trachomatis | Fepuari 2010 | Vaega 4 |
NCT01380483 | Par Pharmaceutical, Inc.|Anapharm | E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi | Ianuari 2000 | Vaega 1 |
NCT00648180 | Mylan Pharmaceuticals | Soifua maloloina | Iulai 2005 | Vaega 1 |
NCT01426269 | Galderma Laboratories, LP | Rosacea | Setema 2011 | Vaega 4 |
NCT02753426 | Iunivesite o Kalefonia, San Francisco | Fa'ama'i fatuga'o tumau|Ma'i fatu fatu | Aperila 2016 | Vaega 1 |
NCT02583282 | Postgraduate Institute of Medical Education and Research | Fa'aleaga Pleural Effusion | Aokuso 1, 2015 | E le agavaa ai |
NCT02927496 | Le Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Iuni 19, 2018 | Vaega 3 |
NCT00652795 | Par Pharmaceutical, Inc.|Anapharm | E Su'esu'eina Bioequivalence I lalo o Tulaga Anapogi | Iulai 2004 | Vaega 1 |
NCT03956212 | University Medical Center Ljubljana|Iunivesite o Ljubljana School of Medicine, Slovenia | Erythema Migrans | Iuni 1, 2017 | E le agavaa ai |
NCT00855595 | Bayer | Papulopustular Rosacea | Fepuari 2009 | Vaega 4 |
NCT03457636 | Derm Research, PLLC | Mata'u | Mati 19, 2018 | Vaega 4 |
NCT02894268 | Sir Run Run Shaw Hospital | Fa'ama'i Helicobacter Pylori | Fepuari 2016 | Vaega 4 |
NCT03465774 | MD Anderson Cancer Center|National Cancer Institute (NCI) | Fa'aleaga Pleural Effusion | Mati 8, 2018 | Laasaga Muamua 1 |
Fa'asologa o vaila'au





Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6galuega faatino o lo'o i lalo ole faamaoniga.

O faiga fa'ava-o-malo maualuga pulega lelei ua fa'ata'atia le fa'avae mautu mo fa'atauga.

O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.

E lagolagoina e le Vaega o Mataupu Tau Fa'apolofesa le tulaga lelei mana'omia ile taimi ole talosaga ma le resitalaina.


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