Daclatasvir Dihydrochloride
Fa'amatalaga
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ose malosi ma tautala tautala.HCV NS5A polotiniinhibitor maEC50s va'aiga o 9-146 pM motele HCV fa'atusa fa'avasegaga.Daclatasvir dihydrochloride ose foi ale anion fa'alela'au felauaiga polypeptide 1B (OATP1B)maOATP1B3inhibitor maIC50s o le 1.5 µM ma le 3.27 µM, fa'asologa.
IC50& Sini
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) ma le HCV replicon genotype 4a) HCV fa'atusa fa'asologa o ituaiga 5a)[1]
Kd: 8 nM (NS5A33-202) ma le 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) ma le 3.27 µM (OATP1B3)[3]
I Vitro
O le Daclatasvir (BMS-790052) o loʻo faʻaalia ai le malosi o le faʻalavelave faʻasaga i genotypes uma na faʻataʻitaʻiina, ma le EC50tau mai le 9pm i le 146pm.Daclatasvir fa'alavelave fa'atusa HCV genotype 1a, 1b, 2a, 3a, 4a ma le 5a fa'atasi ma le EC50tau o le 50pm, 9pm, 71pm, 146pm, 12pm ma le 33pm, faasologa.O le Daclatasvir o se fa'alavelave malosi ole JFH-1 genotype 2a fa'ama'i pipisi lea e toe fa'afo'i ile aganu'u (EC).50=28pm)[1].Daclatasvir (BMS-790052) fusifusia mau i le NS5A33-202 ma le NS5A26-202 ma Kds o 8 nM ma 210 nM, faasologa[2].
Teuina
| Pa'u | -20°C | 3 tausaga |
| 4°C | 2 tausaga | |
| I solvent | -80°C | 6 masina |
| -20°C | 1 masina |
Su'ega Fa'afoma'i
| Numera NCT | Fesoasoani | Tulaga | Aso Amata | Vaega |
| NCT03369327 | Teheran University of Medical Sciences|RojanPharma Pharmaceutical Company | Fa'ama'i Fa'ama'i Hepatitis C, Tali i Togafitiga o|Tagata Immunodeficiency Virus | Ianuari 1, 2017 | Vaega 3 |
| NCT03485846 | R-Pharm|Almedis | Fa'ama'i Hepatitis C Genotype 1b | Novema 27, 2017 | Vaega 2 |
| NCT01016912 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C | Tesema 2009 | Vaega 2 |
| NCT01629732 | Bristol-Myers Squibb | Afete C Virus | Mati 2013 | Vaega 2 |
| NCT01497834 | Bristol-Myers Squibb | Hepatitis C | Ianuari 2012 | Vaega 3 |
| NCT01973049 | Bristol-Myers Squibb | Hepatitis C | Tesema 2013 | Vaega 3 |
| NCT00663208 | Bristol-Myers Squibb | Hepatitis C | Me 2008 | Vaega 2 |
| NCT02576314 | Nofoaga Su'esu'e o Tagata ma le Soifua Maloloina|Beijing 302 Falema'i | Fa'ama'i pipisi o le Hepatitis C | Me 2015 | Vaega 3 |
| NCT02756936 | Nofoaga Su'esu'e Moni, Aikupito|Zeta Pharmaceutical Alamanuia | Soifua maloloina | Fepuari 2016 | Vaega 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute|Iunivesite Cairo | Hepatitis C, Chronic|Hepatocellular Carcinoma | Mati 2016 | Vaega 3 |
| NCT03706898 | Viriom | HIV-1-fa'ama'i|Fa'aletonu le ate | Oketopa 1, 2018 | Vaega 1 |
| NCT02319031 | Bristol-Myers Squibb | Hepatitis C | Fepuari 2015 | Vaega 3 |
| NCT02124044 | National Institutes of Health Clinical Center (CC)|National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | Fepuari 2014 | Vaega 2 |
| NCT02551861 | Bristol-Myers Squibb | Hepatitis C | Tesema 2015 | Vaega 2 |
| NCT00859053 | Bristol-Myers Squibb | Le atoatoa ole ate | Mati 2009 | Vaega 1 |
| NCT01257204 | Bristol-Myers Squibb | Afete C Virus | Tesema 2010 | Vaega 2 |
| NCT03063879 | Teheran Iunivesite o Saienisi Faafomai|Ahvaz Jundishapur Iunivesite o Fomai Saienisi|Shiraz Iunivesite o Saienisi Faafomai|Hamadan Iunivesite o Saienisi Faafomai | Fa'ama'i C, Fa'ama'i|Ta'i Fa'aletonu Renal | Aperila 1, 2017 | Vaega 4 |
| NCT01017575 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C | Tesema 2009 | Vaega 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Hepatitis C | Setema 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatitis C, Fa'ama'i | Mati 29, 2019 | Vaega 2|Vaega 3 |
| NCT03487848 | Bristol-Myers Squibb | Fa'ama'i A'a C|Ta'ita'i Fa'ama'i | Me 18, 2018 | Vaega 2 |
| NCT00904059 | Bristol-Myers Squibb | Hepatitis C | Me 2009 | Vaega 1 |
| NCT02107365 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Fa'ama'i Fa'ama'i Ate C Genotype 4 | Novema 2013 | Vaega 2 |
| NCT02397395 | Janssen R&D Aialani | Fa'aletonu o Gagana | | Me 2015 | Vaega 2 |
| NCT03169348 | Iunivesite o Assiut | Hepatitis C | Novema 1, 2017 | E le agavaa ai |
| NCT02323594 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C | Tesema 2014 | Vaega 1 |
| NCT03537196 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | Hepatitis C|Fa'aogaina o Fualaau Fa'asaina|Viral Hepatitis C | Novema 13, 2018 | Vaega 4 |
| NCT02103569 | Bristol-Myers Squibb | Hepatitis C | Aperila 2014 | Vaega 1 |
| NCT02772744 | Iunivesite o Zagazig|Iunivesite Cairo | Hepatitis C | Novema 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Hepatitis C | Ianuari 2013 | Vaega 3 |
| NCT02496078 | Bristol-Myers Squibb | Hepatitis C | Aokuso 2015 | Vaega 3 |
| NCT01425970 | Bristol-Myers Squibb | Hepatitis C | Me 2012 | Vaega 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatitis C, Genotype 1 | Tesema 2011 | Vaega 3 |
| NCT01573351 | Bristol-Myers Squibb | Afete C Virus | Me 2012 | Vaega 3 |
| NCT01938625 | Janssen R&D Aialani | Hepatitis C, Fa'ama'i | Tesema 12, 2013 | Vaega 2 |
| NCT01492426 | Bristol-Myers Squibb | Hepatitis C | Ianuari 2012 | Vaega 3 |
| NCT03480932 | Johns Hopkins Bloomberg School of Public Health|National Institute on Drug Abuse (NIDA)|YR Gaitonde Center for AIDS Research and Education | Hepatitis C, Fa'ama'i | Fepuari 2, 2018 | Vaega 2|Vaega 3 |
| NCT03163849 | Iunivesite o Assiut | Fa'ama'i Hepatitis i | Setema 1, 2019 | Vaega 3 |
| NCT01581203 | Bristol-Myers Squibb | Afete C Virus | Me 2012 | Vaega 3 |
| NCT01492504 | Bristol-Myers Squibb | Hepatitis C | Fepuari 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|Iunivesite Ain Shams|Ole Suesuega o Fualaau Fa'asaina, Cairo, Aikupito | Ma'isuka Mellitus, Ituaiga 2|Hepatitis C|Fesoasoani Fualaau | Setema 9, 2017 | Vaega 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatitis C, Fa'ama'i | Setema 30, 2014 | Vaega 2 |
| NCT02349048 | Janssen Research & Development, LLC | Afete C Virus | Ianuari 2015 | Vaega 2 |
| NCT03882307 | Iunivesite o Assiut | Hepatitis C, Fa'ama'i | Me 2020 | Laasaga Muamua 1 |
| NCT02758509 | Parc de Salut Mar | Ma'i Hepatitis C|Cirrhosis | Ianuari 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Hepatitis C | Mati 2013 | Vaega 2 |
| NCT03549832 | Iunivesite o Assiut|Iunivesite Sohag|Iunivesete a South Valley | HCV Fa'atasi | Ianuari 1, 2018 | E le agavaa ai |
| NCT02161939 | Bristol-Myers Squibb | Hepatitis C |
| |
| NCT01309932 | Bristol-Myers Squibb | Hepatitis C | Mati 2011 | Vaega 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatitis C | Fepuari 28, 2014 | Vaega 3 |
| NCT02640157 | AbbVie | Fa'ama'i Fa'ama'i C|Virusi Fa'ama'i Ate C|Virusi Fa'ama'i Fa'ama'i Genotype 3 | Tesema 2015 | Vaega 3 |
| NCT02032875 | Bristol-Myers Squibb | Hepatitis C | Mati 2014 | Vaega 3 |
| NCT02624063 | Iunivesite Feterale o São Paulo | Hepatitis C, Fa'ama'i | Tesema 2015 | Vaega 4 |
| NCT00546715 | Bristol-Myers Squibb | Hepatitis C | Novema 2007 | Vaega 1|Vaega 2 |
| NCT01718145 | Bristol-Myers Squibb | Fa'ama'i Fa'ama'i Hepatitis C | Novema 2012 | Vaega 3 |
| NCT01616524 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C (HCV) | Iulai 2012 | Vaega 3 |
| NCT02032901 | Bristol-Myers Squibb | Hepatitis C | Ianuari 2014 | Vaega 3 |
| NCT03540212 | Iunivesite o Ain Shams | Fa'ama'i pipisi ole HCV | Tesema 10, 2017 | Vaega 2|Vaega 3 |
| NCT02097966 | Bristol-Myers Squibb | Hepatitis C |
| |
| NCT02596880 | Teheran Iunivesite o Saienisi Faafomai | Hepatitis C|Cirrhosis | Setema 2015 | Vaega 3 |
| NCT04019717 | Atea Pharmaceuticals, Inc. | Fa'ama'i C|A'a'a C, Fa'ama'i|Afete C|Fa'ama'i Fa'ama'i C| Fa'ama'i Fa'ama'i Fa'ama'i | | Iuni 20, 2019 | Vaega 2 |
| NCT02992457 | Iunivesite o Tanta | Hepatitis C | Ianuari 2015 | Vaega 4 |
| NCT03547895 | Iunivesite o Zagazig | Decompensated Cirrhosis | Iuni 1, 2015 | E le agavaa ai |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Hepatitis C | Novema 2016 | Vaega 3 |
| NCT01051414 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C | Aperila 2010 | Vaega 2 |
| NCT02309450 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Fa'ama'i Fa'ama'i Ate C Genotype 4 | Tesema 2014 | Vaega 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Afete C Virus | Iulai 2012 | Vaega 2 |
| NCT03186313 | Falemai Ate Aikupito|Wadi El Nil Falemai | Hepatitis C | Setema 2016 | Vaega 3 |
| NCT03063723 | Tolu Falemai Fa'atasi, Sun Yat-Sen Iunivesite | Hepatitis C tumau (Fa'aletonu) | Ianuari 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Hepatitis C | Oketopa 2009 | Vaega 1 |
| NCT01725542 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Fa'ama'i Fa'atasi HCV-HIV | Tesema 2012 | Vaega 2 |
| NCT02282709 | Faavae mo Suesuega ate | Hepatitis C | Fepuari 2014 | Vaega 3 |
| NCT02032888 | Bristol-Myers Squibb | Hepatitis C | Fepuari 2014 | Vaega 3 |
| NCT03247296 | MTI Iunivesite | Hepatitis C | Fepuari 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Hepatitis C | Setema 2011 | Vaega 3 |
| NCT02556086 | Bristol-Myers Squibb | Hepatitis C | Tesema 2015 | Vaega 2 |
| NCT01741545 | Bristol-Myers Squibb | Afete C Virus | Mati 31, 2013 | Vaega 3 |
| NCT01866930 | Bristol-Myers Squibb | Fa'ama'i pipisi o le Hepatitis C | Iulai 11, 2013 | Vaega 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatitis C, Fa'ama'i | Ianuari 2015 | Vaega 2 |
| NCT01797848 | Bristol-Myers Squibb | Hepatitis C | Iuni 2014 | Vaega 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Iunivesite Assiut | Hepatitis C | Iuni 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Hepatitis C | Iuni 2014 | Vaega 1 |
| NCT01125189 | Bristol-Myers Squibb | Afete C Virus | Iulai 2010 | Vaega 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Fegalegaleaiga o Vailaau | Novema 19, 2018 | Vaega 1 |
| NCT01012895 | Bristol-Myers Squibb | Hepatitis C | Tesema 2009 | Vaega 2 |
| NCT02565888 | Iunivesite o Radboud | Hepatitis C|HIV | Novema 2015 | Vaega 1 |
| NCT02555943 | Humanity and Health Research Center|Beijing 302 Hospital|Nafang Hospital o Southern Medical University | Fa'ama'i Fa'ama'i Fa'ama'i C|Va'i Fa'atasi HBV| Toe fa'afo'isia le Hepatitis B | Fepuari 2015 | Vaega 2|Vaega 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Southern California Research Center | Hepatitis C|Cirrhosis | Ianuari 2015 | Vaega 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent's Hospital, Korea|Konkuk University Hospital|Cheongju St. Mary's Hospital, Cheongju , Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|O le Katoliko Iunivesite o Korea | Hepatitis C | Fepuari 2016 | Vaega 4 |
| NCT02104843 | Bristol-Myers Squibb | Hepatitis C | Aperila 2014 | Vaega 1 |
| NCT01428063 | Bristol-Myers Squibb | Fa'ama'i Fa'ama'i Hepatitis C | Setema 2011 | Vaega 2 |
| NCT02123654 | Bristol-Myers Squibb | Fa'ama'i Fa'ama'i Hepatitis C | Aperila 2014 | Vaega 3 |
| NCT02565862 | Iunivesite o Radboud | Hepatitis C|Ma'isuka Mellitus|Tagata Inisalini | Ianuari 2016 | Vaega 1 |
| NCT04211844 | Iunivesite o Ain Shams | Hepatitis C | Oketopa 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Fa'ama'i Hepatitis C | Iuni 2009 | Vaega 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Gagana fatuga'o, Fa'ama'i|Hepatitis C | Mati 15, 2019 | Vaega 3 |
| NCT01448044 | Bristol-Myers Squibb | Hepatitis C | Tesema 2011 | Vaega 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Hepatitis C | Iuni 2011 | Vaega 2 |
| NCT01842451 | Vertex Pharmaceuticals Incorporated | Ma'i Hepatitis C|CHC|HCV|Hepatitis C | Iuni 2013 | Vaega 2 |
| NCT02762448 | Tainan Municipal Hospital | Hepatitis c | Iulai 2016 |
|
| NCT02473211 | Nofoaga Su'esu'e o Tagata ma le Soifua Maloloina|Beijing 302 Falema'i | Fa'ama'i pipisi o le Hepatitis C | Ianuari 2015 | Vaega 2|Vaega 3 |
| NCT01455090 | Bristol-Myers Squibb | Hepatitis C | Novema 30, 2011 | Vaega 2 |
| NCT03490097 | Iunivesite o Ain Shams | Ma'i Hepatitis c|Metabolic Syndrome | Tesema 1, 2017 | Vaega 2|Vaega 3 |
| NCT01170962 | Bristol-Myers Squibb | Afete C Virus | Aokuso 2010 | Vaega 2 |
| NCT02333292 | Falemai o le Iunivesite o Valme|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias Falema'i General Universitario de Alicante|Hospital Universitario Araba|Hospital Universitario Virgen Macarena|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Hospital Universitario Virgen Macarena|Complexo Hospitalario de Nacional de Vigo | Navarra|Hospital Clinico Universitario San Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Virgen Regional Universitario| la Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell | Fa'ama'i pipisi o le Hepatitis C | Tesema 2014 |
|
| NCT03200184 | Teheran Iunivesite o Saienisi Faafomai | Hepatitis C | Setema 1, 2016 | Vaega 4 |
| NCT03188276 | Tolu Falemai Fa'atasi, Sun Yat-Sen Iunivesite | Hepatitis C | Fepuari 1, 2016 | Laasaga Muamua 1 |
| NCT01830205 | Bristol-Myers Squibb | Hepatitis C | Setema 2012 | Vaega 1 |
Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6o lo'o i lalo le faamaoniga.
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O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.
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