Dabigatran Etexilate Mesylate
Fa'amatalaga
O le Dabigatran etexilate mesylate (BIBR 1048MS) o se vailaʻau faʻamalosi tautala a Dabigatran.Dabigatran etexilate mesylate ei ai aʻafiaga anticoagulant ma faʻaaogaina mo le puipuia o le venousthromboembolism ma le stroke ona o le fibrillation atrial.
Talaaga
Faʻamatalaga: IC50 Taua: 4.5nM (Ki);10nM(Thrombin-induced platelet aggregation) [1] O le Dabigatran o se mea e mafai ona toe fa'afo'i ma filifili, fa'atosina sa'o o le thrombin (DTI) o lo'o fa'aauau le atina'eina o falema'i e avea o ana vaila'au fa'amalosi tautala, dabigatran etexilate.in vitro: Dabigatran filifili ma toe faʻafefe le thrombin tagata (Ki: 4.5 nM) faʻapea foʻi ma le thrombin-induced platelet aggregation (IC(50): 10 nM), aʻo faʻaalia le leai o se aʻafiaga i luga o isi platelet-stimulating agents.Thrombin generation in platelet -mativa plasma (PPP), fuaina e pei o le endogenous thrombin gafatia (ETP) na taofia le faʻalagolago-faʻalagolago (IC(50): 0.56 microM).Na faʻaalia e Dabigatran aʻafiaga o le anticoagulant faʻalagolago i le faʻaogaina i ituaiga eseese i vitro, faʻaluaina le taimi o le thromboplastin faʻagaoioia (aPTT), taimi o le prothrombin (PT) ma le taimi o le ecarin clotting (ECT) i le PPP tagata i le faʻaogaina o le 0.23, 0.83 ma le 0.18 microM, i le faasologa. 1].i vivo: Dabigatran fa'aumi le fua aPTT-fa'alagolago pe a uma le fa'aogaina o le toto i isumu (0.3, 1 ma le 3 mg/kg) ma manuki rhesus (0.15, 0.3 ma le 0.6 mg/kg).O aʻafiaga faʻamalosi ma faʻalagolago i le taimi na matauina i le dabigatran etexilate na tuʻuina tautala i isumu (10, 20 ma 50 mg / kg) poʻo manuki rhesus (1, 2.5 poʻo le 5 mg / kg), ma le maualuga o aʻafiaga na matauina i le va o le 30 ma le 120. min pe a uma le faʻatonuga, faʻasologa [1].O ma'i na togafitia i le dabigatran etexilate na maua ni nai ta'i fa'ama'i (3.74 dabigatran etexilate vs 3.97 warfarin) ma fa'aitiitia le tu'ufa'atasia o le toto toto ma le fa'ama'i (0.43 dabigatran etexilate vs 0.99 warfarin) i le 100 ma'i-tausaga].Faʻataʻitaʻiga faʻapitoa: O se Iloiloga o Pharmacokinetics ma Pharmacodynamics o le Oral Dabigatran Etexilate i Maʻi Hemodialysis.Vaega1
Teuina
| Pa'u | -20°C | 3 tausaga |
| 4°C | 2 tausaga | |
| I solvent | -80°C | 6 masina |
| -20°C | 1 masina |
Su'ega Fa'afoma'i
| Numera NCT | Fesoasoani | Tulaga | Aso Amata | Vaega |
| NCT02170792 | Boehringer Ingelheim | Soifua maloloina | Fepuari 2001 | Vaega 1 |
| NCT02170974 | Boehringer Ingelheim | Soifua maloloina | Iulai 2004 | Vaega 1 |
| NCT02170831 | Boehringer Ingelheim | Soifua maloloina | Me 1999 | Vaega 1 |
| NCT02170805 | Boehringer Ingelheim | Soifua maloloina | Aperila 2001 | Vaega 1 |
| NCT02170610 | Boehringer Ingelheim | Soifua maloloina | Mati 2002 | Vaega 1 |
| NCT02170909 | Boehringer Ingelheim | Soifua maloloina | Tesema 2004 | Vaega 1 |
| NCT02171000 | Boehringer Ingelheim | Soifua maloloina | Aperila 2005 | Vaega 1 |
| NCT02170844 | Boehringer Ingelheim | Soifua maloloina | Iuni 2004 | Vaega 1 |
| NCT02170584 | Boehringer Ingelheim | Soifua maloloina | Ianuari 2001 | Vaega 1 |
| NCT02170935 | Boehringer Ingelheim | Venous Thromboembolism | Aperila 2002 | Vaega 2 |
| NCT02170636 | Boehringer Ingelheim | Soifua maloloina | Ianuari 2002 | Vaega 1 |
| NCT02170766 | Boehringer Ingelheim | Soifua maloloina | Oketopa 2000 | Vaega 1 |
| NCT02171442 | Boehringer Ingelheim | Soifua maloloina | Aperila 2002 | Vaega 1 |
| NCT02170896 | Boehringer Ingelheim | Soifua maloloina | Oketopa 2001 | Vaega 1 |
| NCT02173730 | Boehringer Ingelheim | Soifua maloloina | Novema 2002 | Vaega 1 |
| NCT02170623 | Boehringer Ingelheim | Soifua maloloina | Fepuari 2002 | Vaega 1 |
| NCT02170116 | Boehringer Ingelheim | Soifua maloloina | Novema 1998 | Vaega 1 |
| NCT02170597 | Boehringer Ingelheim | Soifua maloloina | Aokuso 2003 | Vaega 1 |
| NCT01225822 | Boehringer Ingelheim | Venous Thromboembolism | Novema 2002 | Vaega 2 |
| NCT02170701 | Boehringer Ingelheim | Venous Thromboembolism | Oketopa 2000 | Vaega 2 |
| NCT02170740 | Boehringer Ingelheim | Soifua maloloina | Novema 1999 | Vaega 1 |
| NCT02170922 | Boehringer Ingelheim | Soifua maloloina | Iulai 1999 | Vaega 1 |
Fa'asologa o vaila'au
Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6o lo'o i lalo le faamaoniga.
A'oa'oga fa'ava-o-malo pulega lelei faiga ua faataatia faavae mautu mo le faatauina atu.
O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.
E lagolagoina e le vaega o Mataupu Tau Fa'apolofesa tulaga mana'omia ile taimi ole talosaga ma le resitalaina.
Korea Countec Laina Fa'a'u'u Fagu
Taiuani CVC Faunoa Laina afifiina
Italia CAM Board Packaging Line
Siamani Fette Compacting Machine
Iapani Viswill Tablet Su'esu'e
Potu Pulea DCS
