Venetoclax 1257044-40-8

Fa'amatalaga Puupuu:

Igoa API Fa'ailoga Fa'afouga Aso e muta ai le pateni(US)
Venetoclax 1257044-40-8 CLL Abbvie Iun.27,2031


Fa'amatalaga Oloa

Faailoga o oloa

FAAMATALAGA O MEA FAI

维奈妥拉 Venetoclax 1257044-40-8 I totonu o le Fale
VCL-6A 98549-88-3 I totonu o le Fale
VCL-7A 1235865-75-4 I totonu o le Fale
VCLM2 1228780-72-0 I totonu o le Fale
VCLM2-2HCl 1628047-87-9 I totonu o le Fale
VCLM3 1228779-96-1 I totonu o le Fale

Generic Igoa:venetoclax (ven ET oh klax)
Igoa Fa'ailoga: Venclexta, Venclexta Start Pack

Venetoclax e faʻaaogaina e togafitia ai le leukemia lymphocytic masani poʻo le lymphocytic leukemia laiti i tagata matutua.O le Venetoclax e fa'aaogaina na'o ia pe fa'atasi ma isi vaila'au o le kanesa e togafitia ai nei tulaga.

Venetoclax e faʻaaogaina faʻatasi ma le azacitidine, decitabine, poʻo le cytarabine e togafitia ai le leukemia myeloid acute.O lenei tu'ufa'atasiga e mo le fa'aoga i tagata matutua e 75 tausaga pe sili atu, po'o e le mafai ona fa'aogaina le chemotherapy masani ona o isi ma'i.

O le Venetoclax e tu'uina atu i nisi taimi pe a uma ona le manuia isi togafitiga.

E mafai fo'i ona fa'aogaina le Venetoclax mo fa'amoemoega e le o ta'ua i lenei ta'iala tau vaila'au.

Fa'amatalaga

Venetoclax (ABT-199; GDC-0199) o se mea e sili ona malosi, filifili ma tautala faʻamalosi Bcl-2 inhibitor ma le Ki e itiiti ifo i le 0.01 nM.Venetoclax fa'aosoina le autophagy.

I Vitro

Venetoclax (ABT-199) potently fasiotia FL5.12-BCL-2 sela (EC50=4 nM), Venetoclax (ABT-199) faaalia ai le tele o gaoioiga vaivai e faasaga i FL5.12-BCL-XL sela (EC50=261 nM).ABT-199 o loʻo faʻaalia foʻi le filifilia i suʻesuʻega lua-hybrid suʻega, lea e faʻalavelaveina ai BCL-2-BIM complexes (EC50 = 3 nM) ae e sili atu le aoga i le BCL-XL-BCL-XS (EC50 = 2.2).μM) poʻo MCL-1-NOXA lavelave.

A maeʻa se tui tuʻu tasi o le 12.5 mg i le kilokalama o le mamafa o le tino i xenografts e maua mai i le RS4; 11 sela (ALL), Venetoclax (ABT-199) mafua ai le faʻatupuina o le tumo sili ona maualuga (TGImax) o le 47% (P<0.001) ma le tuputupu aʻe o le tuma tuai (TGD) o le 26% (P<0.05)[1].

Togafitiga o le xenografted faʻamautu (se faʻataʻitaʻiga xenograft mouse o le T-ALL cell line LOUCY) tuma ma Venetoclax (ABT-199) 100 mg / kg mo le 4 aso e maua ai le faʻaitiitia o le mamafa o le leukemia.

Teuina

Pa'u

-20°C

3 tausaga

4°C

2 tausaga
I solvent

-80°C

6 masina

-20°C

1 masina

Fa'asologa o vaila'au

Venetoclax 1257044-40-8

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