Sacubitril Hemicalcium

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Sacubitril Hemicalcium   Totonu o le Fale      

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FAʻAMATALAGA FAʻAMATALAGA

    沙 库 比 曲 半 钙盐 Sacubitril Hemicalcium 1369773-39-6 Totonu o le Fale
    沙 库 比 曲 钠盐 149690-05-1 Totonu o le Fale
    LCZ-4 1426129-50-1 Totonu o le Fale
    LCZ-7 1012341-48-8 Totonu o le Fale
    LCZ-8 1012341-50-2 Totonu o le Fale
    LCZ-9 149690-12-0 Totonu o le Fale

 

Talaʻaga

AHU-377 hemicalcium salt is a hemicalcium salt form o le AHU-377. O se inhibitor o neprilysin ma IC50 taua o le 5 nM [1].

AHU-377 ma le angiotensin II AT1 receptor antagonist valsartan tusia LCZ696 i le 1: 1 molar ratio. LCZ696 o le angiotensin receptor neprilysin taofiofia. E mafai ona faʻaititia le toto maualuga ma ono avea ma fualaʻau fou mo le togafitiga o le fatu faʻaletonu. AHU-377 o se faʻatonuina-vailaʻau, e mafai ona liua e enzymatic cleavage o le ethyl ester i totonu o le gaioiga foliga LBQ657. Ua lipotia mai o le AHU-377 (30 ma le 100 mg / kg, PO) e mafai ona mafua ai aafiaga antihypertensive i se faiga faʻalagolago i se inumaga i DAHI-SS iole. Ae i le DOCA-masima toto maualuga toto, o loʻo faʻaalia ai le faʻaititia vaivai [2, 3].

Faʻamatalaga:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 Me 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. O le ono mafai o le valsartan + AHU377 (LCZ696) i le togafitia o le fatu faʻaletonu. Tomai Faʻapitoa Opin Investig. 2013 Aukuso; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Faʻatusatusaga aoga o le AHU-377, o se neprilysin malosi taofi, i le lua rat faʻataʻitaʻiga o le maualuga-faʻalagolago maualuga. BMC Pharmacology 2011, 11 (Faʻaopopo 1): P33.

Fausaga o vailaʻau

Sacubitril Hemicalcium

FAUTUAINA

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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