Fa'amatalaga

Pitavastatin Calcium (NK-104 hemicalcium) ose hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor malosi.Pitavastatin Calcium (NK-104 hemicalcium) e faʻalavelaveina le faʻapipiʻiina o le cholesterol mai le acetic acid ma le IC50 o le 5.8 nM i sela HepG2.O le Pitavastatin Calcium o se fa'ama'i lelei ole lipoprotein-cholesterol (LDL-C) e fa'atosina lelei ile hepatocyte.Gaioiga e tetee atu i le kanesa.

Talaaga

Pitavastatin Calcium ose fa'atauva'a fa'atauva'a ole enzyme HMGCR (HMG-CoA reductase) e mafua ai le fa'aitiitia o le fa'atupuina ole LDL cholesterol.O isi suʻesuʻega e faʻaalia ai e mafai e pitavastatin ona taofiofia le gaosiga o le okesene i sela endothelial e ala i le taofia o le NADPH oxidase.E le gata i lea, o le pitavastatin e faʻaitiitia ai le faʻaalia o le eNOS mRNA aʻo faʻateleina le tali NO faʻalagolago e faʻaosofia e le acetylcholine ma le calcium ionophore, A23187.E le gata i lea, o le pitavastatin e faʻalavelaveina le faʻatonutonuina o le faʻaogaina o le calcium-activated potassium channel e ala i le faʻaititia o le cholesterol i sela.

Teuina

4°C, puipuia mai le malamalama

* I le solvent: -80°C, 6 masina;-20°C, 1 masina (puipui mai le malamalama)

Fa'asologa o vaila'au

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