Chlorothiazide
Talaaga
Chlorothiazide o se inhibitor o carbonic anhydrase ma e laʻititi le malosi nai lo le acetazolamide. O lenei fa'aputuga ua fa'aalia e poloka ai le toe fa'afo'i o iona o le sodium ma le chloride.
Fa'amatalaga
Chlorothiazide o se vailaʻau faʻamaʻi ma antihypertensive. (IC50=3.8 mM) Manulauti: Isi Chlorothiazide sodium (Diuril) ose vaila'au fa'aaogaina i totonu o le falema'i po'o le fa'aogaina e le tagata lava ia e pulea ai le tele o le vai e feso'ota'i ma le fa'aletonu o le fatu. E faʻaaogaina foi e avea o se antihypertensive. Ole tele o taimi e inu ai ile fua ole pili, e masani ona inu fa'atasi pe faalua ile aso. I totonu o le ICU, e tuʻuina atu le chlorothiazide e faʻafefe ai se maʻi faʻaopoopo i le furosemide (Lasix). O le galue i se masini e ese mai i le furosemide, ma mitiia i totonu e pei o se faʻamalolo toe faʻaleleia o loʻo faʻatinoina e ala i le faʻauʻu nasogastric (NG tube), o vailaʻau e lua e faʻamalosia le tasi i le isi.
Tofotofoga Fa'afoma'i
Numera NCT | Sponsor | Tulaga | Aso Amata | Vaega |
NCT03574857 | Iunivesite o Virginia | Fa'aletonu le fatu|Ma'i le fatu fa'atasi ma le fa'aitiitiga o vaega tu'u'ese|fa'aletonu le fatu|Ma'i cardiovascular. | Iuni 2018 | Vaega 4 |
NCT02546583 | Iunivesite o Yale|National Heart, Lung, and Blood Institute (NHLBI) | Fa'aletonu le fatu | Aokuso 2015 | E le agavaa ai |
NCT02606253 | Vanderbilt University|Vanderbilt University Medical Center | Fa'aletonu le fatu | Fepuari 2016 | Vaega 4 |
NCT00004360 | Nofoaga Autu mo Su'esu'ega (NCRR)|Iunivesete i Matusisifo|Ofisa o Fa'ama'i Seseasea (ORD) | Ma'isuka Insipidus, Nephrogenic | Setema 1995 |
|
NCT00000484 | National Heart, Lung, and Blood Institute (NHLBI) | Fa'ama'i Fa'ato'aga|Ma'i fatu|Ma'i A'a | Aperila 1966 | Vaega 3 |
Fa'asologa o vaila'au





Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6galuega faatino o lo'o i lalo ole faamaoniga.

O faiga fa'ava-o-malo maualuga pulega lelei ua fa'ata'atia le fa'avae mautu mo fa'atauga.

O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.

E lagolagoina e le Vaega o Mataupu Tau Fa'apolofesa le tulaga lelei mana'omia ile taimi ole talosaga ma le resitalaina.


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