Chlorothiazide

Fa'amatalaga Puupuu:

Igoa API Fa'ailoga Fa'amatalaga US DMF EU DMF CEP
Chlorothiazide Diuretics USP/EP      


Fa'amatalaga Oloa

Faailoga o oloa

FAAMATALAGA O MEA FAI

Talaaga

Chlorothiazide o se inhibitor o carbonic anhydrase ma e laʻititi le malosi nai lo le acetazolamide. O lenei fa'aputuga ua fa'aalia e poloka ai le toe fa'afo'i o iona o le sodium ma le chloride.

Fa'amatalaga

Chlorothiazide o se vailaʻau faʻamaʻi ma antihypertensive. (IC50=3.8 mM) Manulauti: Isi Chlorothiazide sodium (Diuril) ose vaila'au fa'aaogaina i totonu o le falema'i po'o le fa'aogaina e le tagata lava ia e pulea ai le tele o le vai e feso'ota'i ma le fa'aletonu o le fatu. E faʻaaogaina foi e avea o se antihypertensive. Ole tele o taimi e inu ai ile fua ole pili, e masani ona inu fa'atasi pe faalua ile aso. I totonu o le ICU, e tuʻuina atu le chlorothiazide e faʻafefe ai se maʻi faʻaopoopo i le furosemide (Lasix). O le galue i se masini e ese mai i le furosemide, ma mitiia i totonu e pei o se faʻamalolo toe faʻaleleia o loʻo faʻatinoina e ala i le faʻauʻu nasogastric (NG tube), o vailaʻau e lua e faʻamalosia le tasi i le isi.

Tofotofoga Fa'afoma'i

Numera NCT Sponsor Tulaga Aso Amata

Vaega

NCT03574857 Iunivesite o Virginia Fa'aletonu le fatu|Ma'i le fatu fa'atasi ma le fa'aitiitiga o vaega tu'u'ese|fa'aletonu le fatu|Ma'i cardiovascular. Iuni 2018

Vaega 4

NCT02546583 Iunivesite o Yale|National Heart, Lung, and Blood Institute (NHLBI) Fa'aletonu le fatu Aokuso 2015

E le agavaa ai

NCT02606253 Vanderbilt University|Vanderbilt University Medical Center Fa'aletonu le fatu Fepuari 2016

Vaega 4

NCT00004360 Nofoaga Autu mo Su'esu'ega (NCRR)|Iunivesete i Matusisifo|Ofisa o Fa'ama'i Seseasea (ORD) Ma'isuka Insipidus, Nephrogenic Setema 1995

NCT00000484 National Heart, Lung, and Blood Institute (NHLBI) Fa'ama'i Fa'ato'aga|Ma'i fatu|Ma'i A'a Aperila 1966

Vaega 3

Fa'asologa o vaila'au

Chlorothiazide

PULEGA UIGA

Puleaina lelei1

Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6galuega faatino o lo'o i lalo ole faamaoniga.

Pulega lelei2

O faiga fa'ava-o-malo maualuga pulega lelei ua fa'ata'atia le fa'avae mautu mo fa'atauga.

Pulega lelei3

O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.

Puleaina lelei4

E lagolagoina e le Vaega o Mataupu Tau Fa'apolofesa le tulaga lelei mana'omia ile taimi ole talosaga ma le resitalaina.

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