Captopril
Fa'amatalaga
Captopril (SQ-14534) o se fa'ailo malosi, fa'atauva'a o le angiotensin-converting enzyme (ACE).
I Vitro
Captopril (SQ-14534) ua faʻaalia e tutusa le faʻamaʻi ma faʻamanuiaga faʻaletino i mea faʻamaʻi faʻamaʻi ma beta-blockers i tagata gasegase maualuga. Captopril (SQ-14534) ua faʻaalia e faʻatuai ai le alualu i luma o le nephropathy o le maʻisuka, ma o le enalapril ma le lisinopril e puipuia ai le atinaʻeina o le nephropathy i tagata mamaʻi masani ma le maʻisuka [1]. O se fua faatatau tutusa o le cis ma le trans states o Captopril (SQ-14534) o loʻo i ai i le vaifofo ma e filifilia e le enzyme naʻo le trans state o le inhibitor lea e maua ai le faʻataʻitaʻiga ma le stereoelectronic faʻatasi ma lona faʻamau faʻamau [2].
E le'i fa'amaonia tuto'atasi e le MCE le sa'o lelei o nei metotia. E mo na'o fa'amatalaga.
Tofotofoga Fa'afoma'i
| Numera NCT | Sponsor | Tulaga | Aso Amata | Vaega |
| NCT03179163 | Penn State University|National Heart, Lung, and Blood Institute (NHLBI) | Ma'itoto, Taua | Iulai 20, 2016 | Vaega 1|Vaega 2 |
| NCT03660293 | Iunivesite o Tanta | Ma'isuka Mellitus, Ituaiga 1 | Aperila 1, 2017 | E le agavaa ai |
| NCT03147092 | Centro Neurológico de Pesquisa ma Reabiitação, Pasila | Ma'a maualuga|Mata'atoto | Fepuari 1, 2018 | Laasaga Muamua 1 |
| NCT00252317 | Rigshospitalet, Tenimaka | Aortic Stenosis | Novema 2005 | Vaega 4 |
| NCT02217852 | Falemai Saina i Sisifo | toto maualuga | Aokuso 2014 | Vaega 4 |
| NCT01626469 | Falemai o Polika ma Tamaitai | Ituaiga 2 Ma'isuka Mellitus | Me 2012 | Vaega 1|Vaega 2 |
| NCT00391846 | AstraZeneca | Fa'aletonu le fatu|Ventricular Disfunction, Agavale | Oketopa 2006 | Vaega 4 |
| NCT00240656 | Iunivesite Faafomai Hebei | To'a maualuga, Pumu | Oketopa 2005 | Vaega 1 |
| NCT00086723 | Northwestern University|National Cancer Institute (NCI) | Tumor Malosi Matutua e le'i fa'ailoaina, Fa'asinomaga Fa'apitoa | Iulai 2003 | Vaega 1|Vaega 2 |
| NCT00663949 | Shiraz Iunivesite o Saienisi Faafomai | Nephropathy o le ma'isuka | Fepuari 2006 | Vaega 2|Vaega 3 |
| NCT01437371 | Falemai o le Iunivesite, Clermont-Ferrand|Servier|LivaNova | Fa'aletonu le fatu | Aokuso 2011 | Vaega 3 |
| NCT04288700 | Iunivesite o Ain Shams | Infantile Hemangioma | Oketopa 1, 2019 | Vaega 4 |
| NCT00223717 | Vanderbilt University|Vanderbilt University Medical Center | toto maualuga | Ianuari 2001 | Vaega 1 |
| NCT02770378 | Iunivesite o Ulm|Tagata Fa'atuatuaina Kanesa|Fa'aputugatupe mo Anticancer, Peleseuma | Glioblastoma | Novema 2016 | Vaega 1|Vaega 2 |
| NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Preeclampsia | Ianuari 2013 | Vaega 4 |
| NCT01545479 | Instituto de Cardiologia o Rio Grande do Sul | Fa'ama'i Renal | Ianuari 2010 | Vaega 4 |
| NCT00935805 | Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Fundação de Amparo i Pesquisa do Estado do Rio Grande do Sul, Pasila | Ma'isuka Mellitus|Matatoto toto | Iulai 2006 |
|
| NCT00742040 | O le Falemai mo Tamaiti Mama'i | Fa'ama'i fatu | Aokuso 2008 | Vaega 2 |
| NCT03613506 | Iunivesite o Wuhan | A'afiaga o le Radiotherapy|Auga o le Captopril | Oketopa 25, 2018 | Vaega 2 |
| NCT00004230 | Northwestern University|National Cancer Institute (NCI) | Kanesa | Oketopa 1999 | Vaega 3 |
| NCT00660309 | Novartis | Ituaiga 2 Ma'isuka Mellitus | Aperila 2008 | Vaega 4 |
| NCT00292162 | NHS Greater Glasgow ma Clyde | Fa'ato'ilalo le fatu|Atrial Fibrillation | Ianuari 2007 | E le agavaa ai |
| NCT01271478 | Coordination de Investigación i Salud, Mekisiko | Fua | Aokuso 2009 | Vaega 4 |
| NCT04193137 | Iunivesite Faafomai Chongqing | Primary Aldosteronism | Novema 30, 2019 |
|
| NCT00155064 | Falemai a le Iunivesite Aoao o Taiwan | Hyperaldosteronism | Iulai 2002 | Vaega 4 |
| NCT01292694 | Vanderbilt University|Vanderbilt University Medical Center | To'a maualuga|Ma'i Tuto'atasi Failu|Matele System Atrophy | Mati 2011 | Vaega 1 |
| NCT00917345 | Falemai a le Iunivesite Aoao o Taiwan|Novartis | Primary Aldosteronism | Ianuari 2008 |
|
| NCT00077064 | Fa'ata'ita'iga Fa'aalaala Fa'aaono Vaega|National Cancer Institute (NCI)|NRG Oncology | Kanesa o māmā|Pulmonary Complications|Radiation Fibrosis | Iuni 2003 | Vaega 2 |
Teuina
| O le pauta | -20°C | 3 tausaga |
| 4°C | 2 tausaga | |
| I solvent | -80°C | 6 masina |
| -20°C | 1 masina |
Fa'asologa o vaila'au
Fautuaga18Poloketi Iloiloga Tulaga Tulaga Lelei ua fa'amaonia4, ma6galuega faatino o lo'o i lalo ole faamaoniga.
O faiga fa'ava-o-malo maualuga pulega lelei ua fa'ata'atia le fa'avae mautu mo fa'atauga.
O le va'aiga lelei e fa'atautaia i le taamilosaga atoa o le olaga o le oloa ina ia mautinoa le lelei ma le togafitiga.
E lagolagoina e le Vaega o Mataupu Tau Fa'apolofesa le tulaga lelei mana'omia ile taimi ole talosaga ma le resitalaina.
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