Fa'amatalaga

Rosuvastatin Calcium (BANM, JAN, USAN) e lauiloa o Rosuvastatin i le US.ma le HMG-CoA reductase inhibitor fa'atauva ma le IC50 o le 11 nM[1].O le Rosuvastatin Calcium e mafai ona poloka le kenera ether-a-go-go related gene (hERG) o loʻo iai i le IC50 o le 195 nM, faʻatuai le toe faʻaleleia o le fatu, ma faʻaumiina ai le umi o gaioiga (APDs) ma faʻasaʻo taimi QT (QTc) vaeluaga [2].O le Rosuvastatin Calcium e fa'aitiitia ai le fa'aaliga o le hERG matua ma le fegalegaleai o le polotini te'i vevela 70 (Hsp70) ma le polotini hERG.Rosuvastatin Calcium e aoga tele i le faʻaitiitia o le lipoprotein maualalo (LDL) cholesterol, triglycerides, ma le C-reactive protein levels [3].

O isi fa'amatalaga i faiga fa'aigoaina o vaila'au: Igoa Fa'ava-o-malo.

Fa'aaliga Taua: O lo'o iai le fa'amaumauga fa'avaomalo a Drugs.com ile fa'asalalauga BETA.O lona uiga o lo'o fa'agasolo pea ma e ono iai ni fa'aletonu.E le'o fa'amoemoe e suitulaga i le poto ma le fa'amasinoga a lau foma'i, foma'i po'o isi tagata tomai fa'alesoifua maloloina.E le tatau ona faauigaina e faʻaalia ai o le faʻaaogaina o soʻo se vailaʻau i soʻo se atunuu e saogalemu, talafeagai pe aoga mo oe.Fa'atalanoa lau foma'i fa'alesoifua maloloina a'o le'i inu so'o se vaila'au.

I totonu o le US, Rosuvastatin (rosuvastatin systemic) o se sui o le vasega o fualaau faasaina statins ma e faʻaaogaina e togafitia ai Atherosclerosis, High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type IIb - Si'itia LDL VLDL, Hyperlipoproteinemia Ituaiga III - Si'itia beta-VLDL IDL, Hyperlipoproteinemia Ituaiga IV - Si'itia VLDL, Hypertriglyceridemia ma le Puipuia o le Fa'ama'i Fa'asa'o.

Talaaga

O se tagata fa'atauva'a fa'atauva'a o le HMG-CoA reductase, o le antilipemic fo'i.

Teuina

Fa'asologa o vaila'au